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New Shockwave Coronary IVL Publication Shows Similar Outcomes in Women And Men
In the patient-level pooled analysis, titled “Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Lesions: Long-Term Sex-Specific Outcomes,” use of IVL for lesion preparation of severely calcified lesions had similar safety and effectiveness in women and men at a one-year follow-up. This is in contrast to atheroablative approaches to vessel preparation, where previous reports show that women are more susceptible to adverse procedural outcomes compared with men.i
The publication reported that despite smaller average reference vessel diameters (2.8 mm vs 3.1 mm) in women (n=106) compared with men (n=342), post-IVL serious angiographic complications, defined as a composite of severe dissection, perforation, abrupt closure, slow-flow, or no-reflow, were similar between women and men (2.2% vs 2.6%, p=0.85). At one-year, major adverse cardiovascular event (MACE) rates were not different between women and men (12.3% vs 13.2%, p=0.52) and there was no difference between women and men in target lesion failure (TLF, 10.4% vs. 11.2% p=0.43). Sex was also not an independent predictor of MACE at one year (HR, 1.24; p = 0.52) after adjusting for major clinical and angiographic covariates.
“The high acute procedural success rate associated with IVL, the infrequent complications and similar one-year clinical outcomes is overall favorable, suggesting that the use of IVL in women is very beneficial in this retrospective analysis,” said
EMPOWER CAD is the first prospective, women-only study of coronary interventions and aims to confirm the benefits of coronary IVL in this under-represented patient population. The first patient was enrolled in
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ihttps://onlinelibrary.wiley.com/doi/10.1002/ccd.28373; Abstract Poster Session, Poster B-9: Gender Difference in Procedural Complications of Atherectomy:
Source: Shockwave Medical, Inc.